Preparation of 1-(4-hydroxyphenyl)piperazine dicyanobromide_Kain Industrial Additive

Overview[1] 1-(4-hydroxyphenyl)piperazine dicyanobromide can be used as a pharmaceutical synthesis intermediate, such as the preparation of 1-acetyl-4-(4-hydroxyphenyl)piperazine, ketoconazole (Ketoconazole) ) is a highly effective, low-toxic, orally effective broad-spectrum antifungal drug. One of its key intermediates is 1-acetyl-4-(4-hydroxyphenyl)piperazine. Preparation[1] 1-(4-hydroxyphenyl)piperazine dicyanobromide is prepared as follows: 1) Synthesis of dibromoethylamine hydrobromide Add 194ml of diethanolamine (210g, 2.0mol)…