Preparation of 2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine_Kain Industrial Additive

Background and overview[1] 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is the key intermediate in the synthesis of bepotastine, 2-[(4-chlorophenyl)(4- Piperidinyloxy)methyl]pyridine is then separated, reacted with ethyl bromobutyrate, and hydrolyzed in three steps to obtain the final product bepotastine. Bepotastine besylate is a drug jointly developed by Japan’s Tanabe Pharmaceuticals and Ube Industries. It is mainly used to treat allergic rhinitis,…