Preparation of 2-bromo-1-chloro-4-trifluoromethoxybenzene_Kain Industrial Additive

Background and overview[1-2] 2-Bromo-1-chloro-4-trifluoromethoxybenzene is a pharmaceutical intermediate, which can be prepared from 2-bromo-4-(trifluoromethoxy)aniline after diazotization and chlorination. 2-Bromo-1-chloro-4-trifluoromethoxybenzene can be used to prepare triazolecarboxylic acid derivatives (such as 4-((4′-chloro-3′-(trifluoromethoxy)-[1, 1,-Biphenyl]-4-yl)thio)-1H-1,1,2,3-triazole-5-carboxylic acid), these derivatives can be used as glycolate oxidase inhibitors. Preparation[1-2] Report 1, A solution of sodium nitrite (0.81g, 11.72mmol) in water (2mL) was…