Preparation of 2-bromo-3′-chloropropiophenone_Kain Industrial Additive

Background and overview[1][2] Rimonabant is a new type of weight-loss drug. 2-Bromo-3′-chloropropiophenone is the key intermediate for the synthesis of rimonabant. Currently, there are very few reports on the synthesis of this intermediate abroad. There are no domestic reports. The existing synthesis method of 2-bromo-3′-chloropropiophenone is to use glacial acetic acid as the solvent, and…