Preparation of 2-bromo-5-methoxyphenylboronic acid_Kain Industrial Additive

Background and overview[1] 2-Bromo-5-methoxyphenylboronic acid can be used as a pharmaceutical synthesis intermediate and can be prepared from 3-methoxyphenylboronic acid, triphenylphosphine sulfide and N-bromosuccinimide. Preparation[1] Under an argon atmosphere, add 3-methoxyphenylboronic acid (9.12g, 60.0mmol), triphenylphosphine sulfide (932mg, 6.00mmol), and dichloromethane (200mL) into a 300 ml eggplant-shaped flask. ), stir it to form a homogeneous solution.…