Preparation of 2-bromo-6-fluorophenol_Kain Industrial Additive

Background and overview[1] 2-Bromo-6-fluorophenol, also called 2-fluoro-6-bromophenol, can be used as a pharmaceutical synthesis intermediate. Using 2-fluorophenol as raw material, through sulfonation, halogenation and deprotection, the intermediate 2-fluoro-6-halogenated phenol can be obtained Preparation[1] Synthesis of 2-fluoro-6-bromophenol: 1) Synthesis of sodium 3-fluoro-4-hydroxybenzenesulfonate (B) (steps a and b, sulfonation reaction): a: Add 112g (1.0mol) A to the…