Preparation of (2-butyl-5-nitro-3-benzofuranyl)[4-[3-(dibutylamino)propoxy]phenyl]methanone_Kain Industrial Additive

Background and overview[1] Synthesis of (2-butyl-5-nitro-3-benzofuryl)[4-[3-(dibutylamino)propoxy]phenyl]methanone as dronedarone hydrochloride intermediate. Dronedarone hydrochloride, chemical name: N-(2-butyl-3-(4-(3-dibutylaminopropoxy)benzoyl)benzofuran-5-yl)methanesulfonamide hydrochloride Salt is an antiarrhythmic drug. Preparation[1] The preparation of (2-butyl-5-nitro-3-benzofuryl)[4-[3-(dibutylamino)propoxy]phenyl]methanone is as follows: The specific steps are as follows: at room temperature, put in butanone (240L), potassium carbonate (17.9kg), 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran (40.0kg) ) and N-(3-chloropropyl)dibutylamine (26.6kg) into the reaction kettle,…