Preparation of 2-chloro-4-methylphenylboronic acid_Kain Industrial Additive

Background and overview[1] 2-Chloro-4-methylbenzeneboronic acid can be used as a pharmaceutical synthesis intermediate and is often used as a raw material for coupling reactions such as Suzuki. 2-Chloro-4-methylbenzeneboronic acid can be prepared by reacting 2-chloro-4-methyl-1-iodobenzene with n-butyllithium. Preparation[1] Step 1: Preparation of 2-chloro-4-methyl-1-iodobenzene Concentrated sulfuric acid (80ml) was added to the stirring mixture of 2-chloro-4-methylaniline…