Preparation of 2-chloro-5-cyanobenzene-1-sulfonyl chloride_Kain Industrial Additive

Background and overview[1] 2-Chloro-5-cyanobenzene-1-sulfonyl chloride is a phenyl cyanide derivative and can be used as a pharmaceutical synthesis intermediate. Structure Preparation[1] The preparation of 2-chloro-5-cyanobenzene-1-sulfonyl chloride is as follows: Dissolve commercially available 4-chloro-3-benzonitrile in 4 parts of THF. To a portion of water, add sodium hydrosulfide (3 equiv.) and stir at 45 °C overnight. TLC…