Preparation of 2′-iodoacetophenone_Kain Industrial Additives

Background and overview[1][2] 2′-iodoacetophenone is an organic intermediate, also called o-iodoacetophenone, which can be prepared by the diazotization reaction of 2-acetylaniline. Preparation[1] To a solution of p-TsOH (22.80 g, 120 mmol) in CH3CN (160 mL) was added the aromatic amine (40 mmol). The resulting amine salt suspension is cooled to 0-5°C. A solution of NaNO2…