Preparation of 2,6-dichlorophenylisothiocyanate_Kain Industrial Additive
Background and overview[1] 2,6-Dichlorophenyl isothiocyanate can be used as a pharmaceutical synthesis intermediate. If 2,6-dichlorophenyl isothiocyanate is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell. ; If eye contact occurs, separate…
Preparation of 2,6-difluoroacetophenone_Kain Industrial Additive
Background 2,6-Difluoroacetophenone is an intermediate in organic synthesis and can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. Preparation [1][2] 1.2. Preparation of 6-difluoroacetophenone: hydrolysis with sulfuric acid/acetic acid Magnesium chloride (167g, 1.75mol) was added to a solution of diethyl malonate (125g, 780mmol) in chlorobenzene (500mL) and the slurry…
Preparation of 2,5-diphenylfuran_Kain Industrial Additive
Background and overview[1] Heterocyclic compounds, especially natural products containing furan and thiophene structures, mostly have good biological activity. Therefore, how to synthesize heterocyclic molecules containing furan and thiophene skeletons with high chemical selectivity and stereoselectivity is particularly important. Enyne compounds are often used to synthesize complex organic compounds due to their good reactivity and multiple…
Preparation of 2,5-dimethoxyphenylethylamine hydrochloride_Kain Industrial Additive
Background and overview[1] 2,5-Dimethoxyphenylethylamine is the main raw material for the synthesis of 5-hydroxytryptamine (5-HT) compounds. Its main synthesis method consists of 2,5-dimethoxybenzaldehyde and nitrate. 2,5-dimethoxy-β-nitrostyrene is prepared by reacting with methane, and is prepared by reduction. 2,5-Dimethoxystyrene derivatives can be used as tyrosine-activating enzyme inhibitors in cancer treatment. Current synthesis of 2,5-dimethoxy-β-nitrostyrene (II). The…
Preparation of 2,5-diamino-1,4-dihydroxybenzene dihydrochloride_Kain Industrial Additive
Background and overview[1][2] Diaminodihydroxybenzene can be used as a monomer for the preparation of polybenzoxazole, by combining 2,5-diamino-1,4-dihydroxybenzene dihydrochloride with diacid, dicarboxylic acid halide, dihydrobenzene Polybenzoxazole can be produced by reacting esters or dinitriles. In order to obtain a high molecular weight polybenzoxazole that can be effectively spun into suitable fibers, a very pure starting…
Preparation of 2,6-di-tert-butyl-4-mercaptophenol_Kain Industrial Additive
Background and overview[1] 2,6-di-tert-butyl-4-mercaptophenol can be used as a pharmaceutical synthesis intermediate and can be used in laboratory research and development and chemical and pharmaceutical synthesis processes. Preparation[1] Step 1: 2,6-di-tert-butyl-4-thiocyanatophenol Add 2,6-di-tert-butylphenol (2.06g, 10mmol), NaBr (1.02g, 10mmol), and NaSCN (1.62g, 20mmol) to a three-necked flask containing MeOH (30mL), respectively. The mixture was cooled in…
Preparation of 2,4,6-tris(4-aminophenyl)-1,3,5-triazine_Kain Industrial Additive
Background and overview[1] 2,4,6-Tris(4-aminophenyl)-1,3,5-triazine is a heterocyclic organic compound that can be used as a pharmaceutical synthesis intermediate. Preparation[1] Preparation of 2,4,6-tris(4-aminophenyl)-1,3,5-triazine: Method 1: Add 1.18g (10mmol) of p-aminobenzonitrile to a 50mL four-necked flask, add 25mL of methylene chloride under magnetic stirring to dissolve it, and slowly add 4mL (45mmol) of trifluoromethanesulfonate dropwise in an…
Preparation of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid_Kain Industrial Additive
Background and overview[1] 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid is a key intermediate in the synthesis of the cardiovascular drug flecainide. The existing technology is mainly obtained by the condensation of gentisic acid and trifluoroethyl trifluoromethanesulfonate. Since gentisic acid and trifluoroethyl trifluoromethanesulfonate are expensive, 2,5-bis(2,2 , 2-trifluoroethoxy)benzoic acid has a higher cost. Structure Preparation[1] A method for preparing 2,5-bis(2,2,2-trifluoroethoxy)benzoic…
Preparation of 2,4-diphenyl-oxazacyclo-5-acid_Kain Industrial Additive
Background and overview[1] 2,4-Diphenyl-oxazacyclo-5-acid is a pharmaceutical intermediate that can be prepared in two steps from (2R,3S)-3-phenylisoserine and trimethyl orthobenzoate. get. It has been reported in the literature that 2,4-diphenyl-oxazacyclo-5-acid can be used to introduce substituents at the C-13 and C-14 positions of paclitaxel, retaining the ring skeleton and necessary functional groups of taxanes, and…
Preparation of 2,2′-bis(trifluoromethyl)diaminobiphenyl_Kain Industrial Additive
Background and overview[1] 2,2′-bis(trifluoromethyl)diaminobiphenyl is also called 2,2′-bis(trifluoromethyl)-4,4’diaminobiphenyl. 2,2′-bis(trifluoromethyl)-4,4’diaminobiphenyl is mainly used in the fields of microelectronics and optoelectronics to prepare extremely low dielectric constant, extremely low surface free energy, extremely high mechanical strength, Colorless and transparent PI material with extremely high wear resistance is the most well-known monomer among all fluorine-containing PI diamine monomers.…
