Preparation of 3-(1-pyrrolidinyl)benzaldehyde_Kain Industrial Additive

Background and overview[1] 3-(1-pyrrolidinyl)benzaldehyde can be used as a pharmaceutical synthesis intermediate. Preparation[1] The preparation of (1-pyrrolidinyl)benzaldehyde is divided into the following steps: Step 1: Synthesis of 2-(3-bromophenyl)-1,3-dioxolane (2): To a stirred solution of 3-bromobenzaldehyde (500 mg, 2.70 mmol) in toluene (10 mL) under an argon atmosphere was added pTSA (catalytic amount) and ethane-1,2-diol (0.5…