Preparation of 3-bromo-5-nitrobenzamide_Kain Industrial Additive

Background and overview[1][2] 3-Bromo-5-nitrobenzamide is a poly(ADP-ribose) polymerase inhibitor. As an anti-tumor agent, it is currently in the clinical research stage and has good clinical prospects. 3-Bromo-5-nitrobenzamide Preparation[2] Method 1: Step 1: Preparation of 3-nitrile-5-nitroaniline. Into a 500ml three-necked flask, add 21.6g (0.1mol) 3-bromo-5-nitroaniline, 10g (0.12mol) cuprous cyanide, 200ml DMF, stir, and heat to React…