Preparation of 3′-fluoroacetophenone_Kain Industrial Additive

Background and Overview 3′-Fluoroacetophenone, also known as m-fluoroacetophenone, is a commonly used drug synthesis intermediate, Preparation[1-2] Method 1, Catalyst [(IPr)AuCl] (3.1mg, 0.5mol%), 3-fluorophenylacetylene (1mmol), methanol (1ml) and water (0.5ml) were added to the 25ml reactor in sequence. The reaction mixture was reacted at 110°C for 6 hours and then cooled to room temperature. The solvent…