Preparation of (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone_Kain Industrial Additive
Background and overview[1] (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone, referred to as (-)β-lactam, is a very potential chiral drug intermediate. There are two isomers, namely (3R, 4S) configuration and (3S, 4R). Among them, the derivative of paclitaxel side chain C-13 of the (3R, 4S) configuration isomer is the most useful for preparing cancer clinical chemotherapy. An important chiral precursor of…
