Preparation of 4,4’-biphenyl dicarboxaldehyde_Kain Industrial Additive
Background and overview[1] 4,4’-Biphenyldicarboxaldehyde is an important organic synthesis intermediate and one of the biphenyl derivatives. Biphenyl derivatives are widely used in medicine, polymer liquid crystals, dyes, pigments, etc. At present, the synthesis methods of aromatic formaldehyde products are divided into indirect electrooxidation methods, phase transfer catalysis methods and organic chemical synthesis methods. The main…
Preparation of 4,5-difluorobenzene-1,2-diamine_Kain Industrial Additive
Background and overview[1] 4,5-Difluorobenzene-1,2-diamine is an organic synthesis intermediate and a chemical pharmaceutical intermediate. It can be used in the research and development of organic synthesis reaction laboratories and chemical pharmaceutical research and development processes. Preparation[1] Preparation of 4,5-difluorobenzene-1,2-diamine: Mix 4,5-difluoro-2-nitroaniline (10g, 57.4mmol), 10% Pdoncarbon (1g) and 100mL methanol together and add it to a…
Preparation of 4,4′-bis(2-bromoacetyl)biphenyl_Kain Industrial Additive
Background and overview[1] 4,4’-Bis(2-bromoacetyl)biphenyl is a key intermediate in the synthesis of the anti-hepatitis C drug daclatasvir. Daclatasvir is a new hepatitis C drug developed by Bristol-Myers Squibb in the United States. On July 24, 2015, the U.S. FDA approved it for the treatment of chronic hepatitis C. The trade name is Daklinza. It is…
Preparation of 4,4′-diaminodiphenyl sulfone_Kain Industrial Additive
Background and overview[1][2] 4-4′-Diaminodiphenyl sulfone is a widely used chemical entity, used both as a hardener in the curing of epoxy resins and as a therapeutic agent for the treatment of bacterial infections in humans or animals. It has been approved as an antibiotic by the Food and Drug Administration since 1963. Regarding its use…
