Preparation of 4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile_Kain Industrial Additive

Background and overview[1] 4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile can be used as an organic synthesis intermediate and pharmaceutical intermediate, and can be used in laboratory organic synthesis processes and chemical and pharmaceutical research and development processes. Preparation[1] Method 1: 4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile is prepared as follows: Weigh 2-(methylthio)pyrimidin-4(3H)-one (3g, 21mmol) and 4-aminobenzonitrile (2.99g, 25mmol) into a 50mL round-bottomed flask, protect with…