Preparation of 4-(4-hydroxyphenyl)butyric acid_Kain Industrial Additives

Background 4-(4-Hydroxyphenyl)butyric acid is an organic synthesis intermediate and pharmaceutical intermediate that can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. Preparation[1-2] Method 1, Step 1 4-(3-Chloro-4-methoxyphenyl)-4-oxobutyric acid (131): AlCl3 (7.78g, 57.4mmol) was dissolved in CH2Cl2 (47 mL) was cooled to 0°C and 2-chloroanisole (5.00 g, 35.0 mmol) in…