Preparation of 4-(4-methylpiperazine)aniline_Kain Industrial Additives

Background and overview[1] 4-(4-methylpiperazine)aniline can be used as a pharmaceutical intermediate. It can be prepared by reducing p-fluoronitrobenzene with N-methylpiperazine after nucleophilic substitution. 4-(4-methylpiperazine)aniline can be used to prepare 2-N-aryl-4-N-aryl-5-fluoropyrimidine compounds. This compound has a high FGFR4 inhibitory effect and can be used as an effective potential anticancer drug. Fibroblast growth factor receptor (FGFR) is…