Preparation of 4-bromobenzoylacetonitrile_Kain Industrial Additive

Background and overview[1] 4-Bromobenzoylacetonitrile can be used as a pharmaceutical synthesis intermediate. It can be prepared from 3-bromobenzoic acid as the reaction raw material. The intermediate 3-bromobenzoic acid methyl ester is first prepared, and 4 is generated under the action of sodium cyanide. -Bromobenzoylacetonitrile. Preparation[1] Step 1: Methyl 3-bromobenzoate To a mixture of 3-bromobenzoic acid…