Preparation of 4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester_Kain Industrial Additive

Background and overview[1] 4-Hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester can be used as a pharmaceutical synthesis intermediate. Phenol is used as raw material to prepare the intermediate 5-phenoxyisobenzofuran-1(3H)-one, which is further reacted to prepare 2-(chloromethyl)-4-phenoxybenzoic acid methyl ester, and N-p 4-Hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester is prepared by reacting tosylglycine methyl ester. Preparation[1] The preparation of 4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid…