Preparation of 5-bromo-2-fluorotrifluorotoluene (alias 2-bromo-5-fluorotrifluorotoluene)_Kain Industrial Additive

Background and overview[1][2] 2-Bromo-5-fluorotrifluorotoluene is a widely used pharmaceutical intermediate. At present, the market demand for 2-bromo-5-fluorotrifluorotoluene as an intermediate is gradually increasing. The synthesis of 2-bromo-5-fluorotrifluorotoluene in the currently published literature and patents mainly uses m-trifluoromethylfluorobenzene as the starting material, and is directly brominated in the presence of acid and brominating agent to obtain…