Preparation of ethoxyformylethyltriphenylphosphine bromide_Kain Industrial Additive

Background and overview[1] Ethoxyformylethyl triphenylphosphine bromide is an organic intermediate that can be prepared in one step from triphenylphosphine and ethyl 2-bromopropionate. Ethoxyformylethyltriphenylphosphine bromide can be used to prepare 2-C-methyl-4,5-O-(1-methylvinyl)-D-arabinonate ethyl ester, 2-C-methyl Ethyl-4,5-O-(1-methylvinyl)-D-arabinonate is a key intermediate in the synthesis of sofosbuvir. Preparation[1] Add 28.8g (0.11mol) triphenylphosphine and 18.1g (0.1mol) ethyl 2-bromopropionate into 157mL…