Preparation of methyl 3-methyl-4-nitrobenzoate_Kain Industrial Additive

Background and overview[1][2] Methyl 3-methyl-4-nitrobenzoate is a pharmaceutical intermediate that can be obtained by one-step esterification of 3-methyl-4-nitrobenzoic acid. It is the starting material for preparing the antihypertensive drug Telmisartan. Preparation[1-2] Report 1, Add 300g 3-methyl-4-nitrobenzoic acid (1.66mol) and 1000mL methanol into a dry 3L three-necked flask equipped with a reflux condenser and a thermometer,…