Preparation of (S)-N-glycidyl phthalimide_Kain Industrial Additive

Background and overview[1] (S)-N-glycidyl phthalimide is also called S-glycidyl phthalimide amine. (S)-N-glycidyl phthalimide is an important intermediate for the preparation of rivaroxaban, new antibiotic linezolid, antifungal thioxazolidinones, and oxazolidinediones. Preparation[1] Step 1, N-(S-2,2-dimethyl-1,3-dioxolane-4-)methylphthalamide Preparation of amines Into a 1-liter four-necked flask connected to a stirrer, thermometer, and condenser tube, add 250 grams of N,N-dimethylformamide (DMF),…