Preparation of Sitagliptin Impurity 13_Kain Industrial Additive

Background and overview[1] Sitagliptin, chemical name (2R)-4-oxo-4-[3-trifluoromethyl-5,6-dihydro[1,2,4]triazole[4 , 3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)-butan-2-amine, which is a dipeptide developed by Merck, USA The first product of DPP-VI (DPP-VI) inhibitor. In October 2006, its phosphate monohydrate was approved by the US FDA as the first dipeptidyl peptidase-VI (DPP-VI) inhibitor for clinical use in the treatment of type 2 diabetes. The advantage…