Synthesis of 5-fluoro-2-hydroxyacetophenone_Kain Industrial Additive

Overview 5-Fluoro-2-hydroxyacetophenone, also known as 2-acetyl-4-fluorophenol, is an important pharmaceutical intermediate that can be used as a synthetic intermediate for a variety of β-blockers and has broad applications. market expectation. Synthesis【1】【2】 The currently reported general preparation method is to use p-fluorophenol as raw material, undergo hydroxyl acylation, and then use Fries rearrangement to synthesize it.…