Synthetic route of 4-chloro-3-nitrobenzene_Kain Industrial Additive

Overview[1][2] 4-Chloro-3-nitrobenzene is the main raw material for the synthesis of rheumatoid arthritis treatment drug iguratimod (T-164). There is no industrial production in China and it mainly relies on imports. Its traditional synthesis method It is mainly produced from p-nitroanisole as raw material through a five-step reaction of reduction, acetylation, nitration, hydrolysis, and diazochlorination. However,…